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British Journal of Anaesthesia, 1985, Vol. 57, No. 3 300-305
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PREMEDICATION BEFORE DAY SURGERY

A Double-Blind Comparison of Diazepam and Placebo

HENRIK JAKOBSEN, M.D.*, JENS B. HERTZ, M.D., JYTTE R. JOHANSEN, M.D., AKSEL HANSEN, M.D., D.A. and KLAUS KØLLIKER, M.D., D.A.

Department of Surgery and Anaesthesiology, Frederiksborg County Hospital Hørsholm, Denmark.

* Address for correspondence: Rævehøjvej 14 A, DK-2800 Lyngby, Denmark.

Premedication with diazepam 0.25 mg kg–1 by mouth was compared with placebo in a doubleblind trial in patients undergoing day-case surgery under general anaesthesia. Diazepam decreased significantly preoperative discomfort and apprehension. The patients were discharged on time regardless of the type of premedication, and complaints at the time of discharge and on the following day could be related only to the length of anaesthesia and not to the type of premedication. Premedication given early in the morning remained effective for up to 6 h.


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