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British Journal of Anaesthesia, 1985, Vol. 57, No. 3 294-299
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF MIDAZOLAM, DIAZEPAM AND PLACEBO I.M. AS PREMEDICATION FOR REGIONAL ANAESTHESIA

A Randomized Double-Blind Study

K. REINHART, M.D., G. DALLINGER-STILLER, R. DENNHARDT, M.D., G. HEINEMEYER, M.D.* and K. EYRICH, M.D.

Department of Anaesthetics and Operative Intensive Care, Klinikurn Steglitz der Freien Unversität Berlin Hindenburgdamm 30, 1000 Berlin West 45
*Institute for Clinical Pharmacology, Klinikurn Steglitz der Freien Unversität Berlin Hindenburgdamm 30, 1000 Berlin West 45

In a randomized double-blind study, midazolam 0.1 mg kg–1 i.m. was compared with diazepam 0.2 mg kg–1 and placebo as premedication for patients undergoing urological interventions under spinal anaesthesia. The sedative and anxiolytic effects of midazolam were evident 5–10 min after administration, and were maximum between 30 and 90 min. After this, rapid recovery was observed. More than 90% of the patients receiving midazolam were totally or partially amnesic for the procedures in the induction room and the operation theatre. Amnesia was not seen in the patients receiving diazepam or placebo and, in contrast to midazolam, diazepam had almost no sleep-inducing effect. In a few patients, the depth of sleep achieved with midazolam 0.1 mg kg–1 was such that co-operation was impaired.


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