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British Journal of Anaesthesia, 1985, Vol. 57, No. 3 275-284
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia


research-article

FENTANYL AND BUPIVACAINE MIXTURES FOR EXTRADURAL BLOCKADE

F. S. RUCCI, M.D., L.D., M.D. CARDAMONE, M.D. and P. MIGLIORI, M.D.

Servizio di Anestesia e Rianimazione, Ospedale Umberto I 03100, Frosinone, Italy

In a prospective double-blind study, single dose lumbar extradural blockade was instituted in 80 healthy male patients undergoing lower abdominal surgery. Patients were assigned randomly to one of four groups. Each group received treatment with 0.5% bupivacaine 20 ml containing adrenaline 1:200 000. To this solution was added fentanyl 0, 50, 100 or 200 µg. The time to regression of analgesic blockade was significantly prolonged (P < 0.05) only with mixtures containing fentanyl 200 µg; no effect was demonstrated with lower doses of the opioid. However, the degree of motor blockade was less intense and incomplete S1-blockade (root-jumping) was more frequent with mixtures containing increasing doses of fentanyl. Patients treated with bupivacaine—fentanyl mixtures shivered less than the control group and showed fewer instances of acute hypotension. The side-effects observed were minor.


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