Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by FELDT-RASMUSSEN, B. F.
Right arrow Articles by HANEL, H. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by FELDT-RASMUSSEN, B. F.
Right arrow Articles by HANEL, H. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1985, Vol. 57, No. 2 204-207
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF A MIXTURE OF PYRIDOSTIGMINE AND ATROPINE ON FORCED EXPIRATORY VOLUME (FEV1), AND SERUM CHOLINESTERASE ACTIVITY IN NORMAL SUBJECTS

B. F. FELDT-RASMUSSEN, M.D., K. GEFKE, M.D., H. MOSBECH, M.D. and H. K. HANEL, M.SC.

Department of Anesthesiology Frederiksborg County Hospital, DK-3400 Hillered, Denmark
Medical Department B and Allergy Clinic Frederiksborg County Hospital, DK-3400 Hillerod, Denmark
Department of Clinical Chemistry Bispebjerg Hospital, DK-2400 Copenhagen, Denmark

Correspondence to B. F.-R., Steno Memorial Hospital, Niels Steensensvej 2, DK-2820 Gentofte, Denmark.

Pyridostigmine 0.143 mg kg–1 (maximum 10 mg) and atropine 0.0143 mg kg–1 (maximum 1 mg) were administered i.v. to six healthy male volunteers. Peripheral venous blood samples were drawn for measurement of serum cholinesterase activity. Maximum inhibition of the enzyme was found 5 min after injection with a decrease to 27 ± 5% (mean ± SEM) of the original activity. Forced expiratory volume in the first 1s (FEV1) was measured at fixed time intervals for 90 min. No decrease in FEV1 was observed; on the contrary, there was a small increase. We conclude that atropine effecively antagonizes the muscarinic side-effects of pyridostigmine on bronchial smooth muscle tone and bronchial secretions, when administered in clinical doses to normal human subjects.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.