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British Journal of Anaesthesia, 1985, Vol. 57, No. 2 184-187
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON BETWEEN GLYCOPYRROLATE AND ATROPINE IN A MIXTURE WITH NEOSTIGMINE FOR REVERSAL OF NEUROMUSCULAR BLOCKADE

Studies in patients following open heart surgery

M. G. SALEM, M.B., CH.B., D.A., F.F.A.R.C.S.*, J. C. RICHARDSON, M.B., CH.B.(HONS), F.F.A.R.C.S., G. A. MEADOWS, M.B., CH.B., F.F.A.R.C.S., G. LAMPLUCH, M.B., CH.B., F.F.A.R.C.S. and K. M. LAI, M.B., CH.B., F.F.A.R.C.S.

Department of Anaesthetics, Broadgreen Hospital Thomas Drive, Liverpool L14 3LB

Atropine and glycopyrrolate were compared in a mixture with neostigmine for reversal of neuromuscular blockade in patients undergoing open heart surgery. In patients not receiving ß-blocking drugs, glycopyrrolate was shown to possess advantages over atropine in terms of a lower initial increase in heart rate, better protection against the muscarinic effects of neostigmine, and smaller increases in rate-pressure product. The concomitant administration of ß-adrenergic blocking therapy significantly attenuated the effect of reversal on heart rate and the differences between atropine and glycopyrrolate were not significant. There was no difference in the incidence of arrhythmias between patients who received ß-blocking drugs and those who did not.

*Present address: Royal Liverpool Hospital, Prescot St, Liverpool L7 8XP.


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