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British Journal of Anaesthesia, 1985, Vol. 57, No. 2 169-173
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF THE COGNITIVE EFFECTS OF PREMEDICATION WITH HYOSCINE AND ATROPINE

S. ANDERSON, B.A., M.PHIL., R. McGUIRE, B.SC., M.A., M.ED. and D. McKEOWN, M.B., CH.B., F.F.R.A.C.S.

Department of Psychiatry, University of Edinburgh
Department of Anaesthetics, Royal Infirmary Edinburgh

An investigation was carried out comparing the nature and duration of the cognitive effects of atropine and hyoscine. Thirty patients undergoing a minor gynaecological operation were randomly assigned to one of three groups to receive hyoscine, atropine or placebo as premedication. A battery of psychological tests was administered before premedication, 30 min after premedication, and 1 and 3 h following operation. The tests included orientation questions, simple tasks such as reciting the alphabet, memory tests, a reactiontime test and two tests of visuo-motor co-ordination. The results showed that hyoscine had detrimental effects on memory and on motor tasks compared with placebo, while atropine did not. In addition, the effects on motor performance had not disappeared 3 h after operation.


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