Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (65)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by AUSEMS, M. E.
Right arrow Articles by HUG, C. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by AUSEMS, M. E.
Right arrow Articles by HUG, C. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1985, Vol. 57, No. 12 1217-1225
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

other

AN EVALUATION OF THE ACCURACY OF PHARMACOKINETIC DATA FOR THE COMPUTER ASSISTED INFUSION OF ALFENTANIL

M. E. AUSEMS§, D. R. STANSKI* and C. C. HUG{dagger}

Department of Anaesthesiology, University of Leiden Hospital Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands

The accuracy of using average alfentanil pharmacokinetic data in a computer assisted infusion pump (TIAC) to predict alfentanil plasma concentrations was tested in 35 patients {divided into three groups) receiving alfentanil and nitrous oxide in oxygen anaesthesia for lower and upper abdominal surgery. By frequently measuring the arterial plasma concentration, it was possible to determine the average prediction error for individual patients and for groups of patients. For the groups, there were no significant systematic over- or underpredictions of the alfentanil plasma concentrations (bias). However, there existed a moderate degree of variability (imprecision) within the groups, caused by deviations of measured and predicted plasma concentrations in the individual patients within each group. As a result, prediction errors of 22.2-32.5% can be expected with the average pharmacokinetic data used in this study to drive TIAC. It was concluded that, as a result of the moderate degree of imprecision, it is unwise to rely totally on the absolute values of alfentanil plasma concentrations predicted by a computer-regulated infusion pump such as TIAC. However, such devices can be used to attain rapidly a relatively stable plasma concentration that can be adjusted (titrated) to the requirements of an individual patient during anaesthesia.

§ Overhovenerstr. 12, 6131 B2 Sittard, The Netherlands

*Department of Anesthesia and Medicine (Clinical Pharmacology), Stanford University Medical Center, Stanford, California 94305, U.S.A.

{dagger}Department of Anesthesiology and Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, U.S.A.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
A. Ouattara, G. Boccara, S. Lemaire, U. Kockler, M. Landi, E. Vaissier, P. Leger, and P. Coriat
Target-controlled infusion of propofol and remifentanil in cardiac anaesthesia: influence of age on predicted effect-site concentrations{dagger}
Br. J. Anaesth., May 1, 2003; 90(5): 617 - 622.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.