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British Journal of Anaesthesia, 1985, Vol. 57, No. 12 1213-1216
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ANTAGONISM OF THE MUSCARINIC EFFECTS OF EDROPHONIUM WITH ATROPINE OR GLYCOPYRROLATE

A Comparative Study R.

K. MIRAKHUR

Department of Clinical Anaesthesia, Royal Victoria Hospital Grosvenor Road, Belfast BT12 6BA.

The efficacy of atropine or glycopyrrolate in doses of 10 or 20 µg kg–1 and 5 or 10 µgkg–l, respectively, has been compared when administered to block the muscarinic effects of edrophonium 0.5 µg kg–1 administered for the reversal of neuromuscular blockade. Both doses of atropine and the higher dose of glycopyrrolate prevented any edrophonium-induced decreases in heart rate; glycopyrrolate at this dose was associated with tachycardia. Atropine and edrophonium could be safely administered together in a mixture. The control of oropharyngeal secretions was adequate even with the lower doses of both anticholinergic agents. Atropine 10 µg kg–1 appears to be a better anticholinergic agent for use with edrophonium.


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