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British Journal of Anaesthesia, 1985, Vol. 57, No. 12 1204-1208
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ATTEMPTED ACCELERATION OF THE ONSET OF ACTION OF PANCURONIUM*

Effects of Divided Doses in Infants and Children

J.C. BEVAN, F. DONATI and D.R. BEVAN

Department of Anaesthesia, Montreal Children's Hospital Montreal, Quebec, Canada
Department of Anaesthesia, Royal Victoria Hospital 687 Pine Avenue West, Montreal, Quebecm Canada H3A 1A1.

Correspondence to D. R. B.

The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0–1 yr (n = 20); 1–3 yr (n = 20); 3–10 yr (n = 20)) were studied during nitrous oxide-oxygenhalothane anaesthesia using train-of-four stimulation, and the results were compared with data obtained previously in adults. The time to onset correlated with the patient's age, and an additional, small acceleration was produced following divided doses which did not alter the duration or pattern of neuromuscular blockade. It was concluded that, in children, divided doses of pancuronium are unlikely to offer important clinical advantages.

*Presented at the Annual Meeting of American Society of Anesthesiologists at New Orleans, 1984.


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