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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1113-1118
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

case-report

ANAESTHESIA AND PROGRESSIVE MUSCULAR DYSTROPHY

C. L. SMITH, B.SC., M.B., CH.B., F.F.A.R.CS., D.R.C.O.G. and G. H. BUSH, M.A., D.M., F.F.A.R.C.S., D.A.

Department of Paediatric Anaesthesia, Alder Hey Children's Hospital Liverpool

The presentation and features of Duchenne's progressive muscular dystrophy (Duchenne's PMD) are described and the increased risks associated with anaesthesia are considered. Hazards associated with induction of anaesthesia and immediate postoperative recovery have been stressed in recent case reports, and these are summarized. Features of a hyperpyrexia-like response including cardiac arrest, increased serum creatine phosphokinase concentration, myoglobinuria and metabolic acidosis following suxamethonium or halothane, or both, have been described in patients with Duchenne's PMD. Subsequent in vitro muscle tests have suggested that it is possible that a malignant hyperpyrexia response to general anaesthesia may occur. Six children known to have Duchenne's PMD who developed delayed respiratory insufficiency following anaesthesia and required controlled pulmonary ventilation are reported. In five of the children, cardiac arrest occurred despite apparently adequate respiratory support. Suxamethonium was common to the anaesthetic received by all six patients. In one of these patients subsequent anaesthetics, without suxamethonium, were uneventful and delayed muscle weakness did not occur.


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