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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1107-1109
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF DIAZEPAM ON DRUG ABSORPTION AND GASTRIC EMPTYING IN MAN

B. ADELHØJ, M.D., O. U. PETRING, M.D., J. BRYNNUM, M. IBSEN and H. E. POULSEN, M.D.

Department of Anaesthesiology, Kommunchospitalet Copenhagen, Denmark
Medical Department A, Rigshospitalet (State University Hospital) Copenhagen, Denmark

Address for correspondence: Department of Anesthesia, Gentofte Hospital, DK-2900 Hellerup, Denmark.

Paracetamol 20mg kg–1 dissolved in 200 ml of water was given by mouth to seven healthy volunteers, together with a single i.v. dose of diazepam 0.2 mg kg–1 or saline 0.04 ml kg–1. This study demonstrated that the rate of paracetamol absorption was not significantly changed by diazepam, indicating that there was no delay in gastric emptying attributable to diazepam per se.


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