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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1095-1099
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF MEPTAZINOL ON NEUROMUSCULAR TRANSMISSION IN THE ISOLATED RAT PHRENIC NERVE-DIAPHRAGM PREPARATION*

S. K. STRAHAN, B.SC., M.B.CH.B., F.F.A.R.C.S., B. J. PLEUVRY, M.SC., PH.D., M.P.S. and C. Y. MODLA, H.N.C.

Departments of Anaesthesia and Pharmacology, Stopford Building, University of Manchester Oxford Road, Manchester M13 9PT.

Meptazinol has been shown to have significant effects on neuromuscular transmission in the isolated rat phrenic nerve-diaphragm preparation. The response of the preparation to indirect electrical stimulation was increased in a concentration-dependent manner by meptazinol hydrochloride 2–32 µg ml–1. Meptazinol 0.5–2 µg ml–1 antagonized the effects the tubocurarine on this preparation, and in concentrations of 1 µg ml–1and greater, potentiated suxamethonium. These effects were similar to those obtained with neostigmine and it was demonstrated that meptazinol had significant anti-cholinesterase activity in the concentrations used. Inhibition of cholinesterase with ecothio-pate revealed a neuromuscular blocking activity of meptazinol in concentrations as low

*A preliminary account of some of this work was presented to the Anaesthetic Research Society, June 31, 1984.


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