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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1089-1094
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INTERACTION OF MIDAZOLAM WITH TWO NON-DEPOLARIZING NEUROMUSCULAR BLOCKING DRUGS IN THE RAT IN VIVO SCIATIC NERVE-TIBIALIS ANTERIOR MUSCLE PREPARATION

J. J. DRIESSEN, M.D, T. B. VREE, PH.D, J. VAN EGMOND, PH.D, L. H. D. J. BOOIJ, M.D., PH.D and J. F. CRUL, M.D., PH.D

Department of Anaesthesiology, Catholic University of Nijmegen Geert Groote Plein Zuid, 10,6525 GH, Nijmegen, The Netherlands.

Studies of the possible interactions between the water-soluble benzodiazepine, midazolam, and two non-depolarizing neuromuscular blocking drugs, vecuronium and tubocurarine, were performed in the rat in vivo sciatic nerve-tibialis anterior muscle preparation. Midazolam 0.5 and 5 mg kg–1 caused 17% and 34% depression of the twitch height, respectively, once a steady-state blockade of the twitch height had been induced by vecuronium. The potentiation of the tubocurarine steady state blockade by midazolam 5 mg kg–1 was quantitatively equal to that of vecuronium, but was slower in onset. The buffer solvent of midazolam 5 mg kg–1 did not change the steady-state blockade of vecuronium. Midazolam 5 mg kg–1 caused a shift to the left of the cumulative dose-response curves of vecuronium.


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