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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1077-1084
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

MEPTAZINOL—A CAUSE OF RESPIRATORY DEPRESSION IN GENERAL ANAESTHESIA

D. J. WILKINSON, M.B., B.S., F.F.A.R.C.S., S. A. O'CONNOR, M.B., B.S., B.SC., F.F.A.R.C.S.,, G. R. DICKSON, B.SC., M.SC., PH.D. and H. F. DRAKE, M.B.,B.S., B.sc., F.F.A.R.C.S.

Department of Anesthesia, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE.
Department of Medical Electronics, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE.

Correspondence and reprint requests to D. J. W.

The respiratory effects of meptazinol 1 mg kg–1 have been compared with those of pethidine 0.5 mg kg–1 and 1 mg kg–1 in a double-blind trial in 30 patients undergoing arthroscopic meniscectomy under general anaesthesia. Respiratory depression was seen in all treatment groups. Pethidine 1 mg kg–1 produced respiratory depression which was greater than that produced by meptazinol 1 mg kg–1. The least depressant respiratory effects were seen in the group receiving pethidine 0.5 mg kg–1. We submit that the measurement of tidal volume enhances the assessment of the respiratory effects of analgesic drugs during anaesthesia.


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