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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1067-1072
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

A COMPARISON OF ATRACURIUM AND ALCURONIUM DURING HALOTHANE ANAESTHESIA BY MEASUREMENT OF THE TRAIN-OF-FOUR RESPONSE OF THE ADDUCTOR POLLICIS MUSCLE AND CLINICAL OBSERVATION

L. P. S. LIN, M.B., B.S., F.F.A.R.C.S.* and J. HOMI, M.B., B.S., D.OBST. R.C.O.G., F.A.C.A., F.F.A.R.C.S.

Department of Anaesthetics and Intensive Care, University Hospital of the West Indies Mona, Kingston 7, Jamaica, West Indies

*Address for correspondence: c/o Ardann Cottage, Goldsborough, Nr. Knaresborough, N. Yorkshire.

Atracurium and alcuronium have been compared during halothane anaesthesia, by measurement of the mechanical response of the adductor pollicis muscles to train-of-four stimulation and by clinical observation. Atracurium appeared significantly shorter-acting than alcuronium. However, results suggested that the action of alcuronium may not be of "medium duration ". A comparison of three indices of muscle twitch response to the train-of-four nerve stimulation, seemed to indicate that the D'/D ratio gave the best overall index of neuromuscular blockade in this study.


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