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British Journal of Anaesthesia, 1985, Vol. 57, No. 11 1060-1062
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF CUMULATIVE AND SINGLE BOLUS DOSE TECHNIQUES FOR DETERMINING THE POTENCY OF VECURONIUM

F. M. GIBSON, M.D., F.F.A.R.C.S., R. K. MIRAKHUR, M.D., F.F.A.R.C.S., R. S. J. CLARKE, M.D., F.F.A.R.C.S. and G. G. LAVERY, M.D., F.F.A.R.C.S.

Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building 97 Lisburn Road, Belfast BT9 7BL
Department of Clinical Anaesthesia, Royal Victoria Hospital Grosvenor Road, Belfast BT12 6BL

The potency of vecuronium was determined using single bolus dose administrations of 10–50 µg kg–1in 28 patients anaesthetized with thiopentone, nitrous oxide, oxygen and fentanyl. The results were compared with those previously obtained using a cumulative dose technique in a comparable group of 10 patients. The 50% and 95% blocking doses (ED50and ED95) of vecuronium were found to be 23.1 and 39.6 µg kg–1, respectively. These were significantly lower than the 30.5 and 56.7µg kg–1 obtained previously using the cumulative dose technique. We recommend the use of single bolus dose method of determining potency for relatively shorter-acting drugs like vecuronium.


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