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British Journal of Anaesthesia, 1985, Vol. 57, No. 10 994-996
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DILTIAZEM INHIBITS HALOTHANE-INDUCED CONTRACTIONS IN MALIGNANT HYPERTHERMIA-SUSCEPTIBLE MUSCLES IN VITRO

W. K. ILIAS, M.D., C. H. WILLIAMS, PH.D., R. T. FULFER, M.D. and S. E. DOZIER, B.S.

Department of Anaesthesiology, Texas Tech University Health Science Center, Regional Academic Health Center 4800 Alberta Avenue, El Paso, Texas 79905, U.S.A.

Reprint requests to C.H.W. (Director of Anaesthesiology Research)

The ability of diltiazem to suppress halothane and halothane-caffeine induced contractures in malignant hyperthermia (MH) susceptible pig muscle, was tested in vitro. Muscle specimens were divided into two groups and tested with a modified halothane-caffeine contracture test. One group acted as the control; the other group was pretreated with diltiazem 20 µmol litre–1. The control muscles developed contractures attributable to halothane and halothane-caffeine, whereas the diltiazem-treated specimens did not. Increases in muscle twitch tension as a result of halothane orhalothane-caffeine exposure occurred intreated and untreated specimens, but were significantly delayed in the presence of diltiazem. Muscle exhaustion observed after halothane and halothane-caffeine exposure in the control specimens did not occur in the diltiazem treated muscles.

Visiting Professor from The University of Vienna


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