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British Journal of Anaesthesia, 1985, Vol. 57, No. 10 954-955
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

BACLOFEN PROLONGS THE ANALGESIC EFFECT OF FENTANYL IN MAN

A. E. PANERAI, M.D., R. MASSEI, M.D., E. DE SILVA, M.D., P. SACERDOTE, PH.D., G. MONZA, M.D. and P. MANTEGAZZA, M.D.

Department of Pharmacology, University of Milano Via Vanvitelli 32, 20129 Milano, Italy
Department of Anaesthesiology, University of Milano Via Vanvitelli 32, 20129 Milano, Italy

Correspondence to A.E.P. (Department of Pharmacology).

Pretreatment with baclofen prolonged the duration of fentanyl-induced analgesia from 18 to 30 min in patients undergoing neurosurgical anaesthesia (fentanyl plus nitrous oxide in oxygen). This observation is consistent with a potentiating effect of GABA on opioid analgesia.


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