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British Journal of Anaesthesia, 1985, Vol. 57, No. 10 949-953
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

POSTOPERATIVE ANALGESIA WITH DUROMORPH

L. CHARWAY, M.B., CH.B., F.F.R.A.C.S.I., T. N. CALVEY, B.Sc., M.D. PH.D., N. E. WILLIAMS, M.B., CH.B., F.F.R.A.C.S. and G. R. MURRAY, B.Sc., PH.D.

Department of Pharmacology and Therapeutics, University of Liverpool Liverpool L69 3BX and Whiston Hospital, Prescot, Merseyside L35 5DR
School of Pharmacy, Liverpool Polytechnic Liverpool L3 3AF

The analgesic effects and bioavailability of a slow-release preparation of morphine (Duromorph) were studied in 12 patients with acute postoperative pain. Duromorph produced significant analgesia within 1–2 h of administration i.m., and there was a progressive decrease in the mean pain score for at least 8 h. None of the patients requested or received additional analgesia within 12 h, and the incidence of side-effects was similar to that associated with i.m. morphine. During the 8-h study, plasma concentrations of morphine slowly increased for 3 h, and then gradually declined. After 3 h, concentrations were invariably greater than those produced by conventional doses of morphine sulphate i.m. The study confirmed that Duromorph was an effective analgesic with a prolonged duration of action, which was suitable for the management of postoperative pain.

Present address: Wyeth Laboratories, Maidenhead, Berks SL6 OPH.


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