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British Journal of Anaesthesia, 1985, Vol. 57, No. 10 1022-1025
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

HAEMORRHAGE DECREASES THE ANAESTHETIC REQUIREMENT FOR KETAMINE AND THIOPENTONE IN THE PIG

R. B. WEISKOPF, M.D. and M. S. BOGETZ, M.D.

Departments of Anesthesia, University of California San Francisco, and San Francisco General Hospital, 1001 Potrero Avenue, Room 3S50, San Francisco, California 94110, U.S.A.

The anaesthetic requirements of ketamine and thiopentone were studied in eight pig littermates during normovolaemia and after haemorrhage (30% bloodloss). Four animals received ketamine and four thiopentone, and the minimal anaesthetic doses of both drugs were determined. Moderate hypovolaemia decreased the anaesthetic requirements significantly and similarly: thiopentone 33±5%; ketamine 40±5% (mean±SEM).


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