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British Journal of Anaesthesia, 1985, Vol. 57, No. 10 1006-1011
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF THE VASOACTIVITY OF AMIDE AND ESTER LOCAL ANAESTHETICS

An Intradermal Study

D. G WILLATTS, M.A., M.B., B.S., F.F.A.R.C.S and F. REYNOLDS, M.D., F.F.A.R.C.S.

Anaesthetic Unit, St Thomas's Hospital Medical School London SE1 7EH

Reprint request to F.R.

The vascular effects and duration of action of two ester-linked local anaesthetics, procaine and amethocaine, and four amide-linked local anaesthetics, cinchocaine, lignocaine, mepivacaine and prilocaine, were investigated in 10 volunteers by intradermal injection using a double-blind technique. Procaine and amethocaine produced marked vasodilatation; weal formation was observed at 80% of the amethocaine injection sites. Mepivacaine had a marked vasoconstrictor effect; the other three agents produced more variable vasoactivity. Duration of action was concentration-dependent for all six drugs, the slopes of the log dose-duration plots reflecting the observed vasoactivity.


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