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British Journal of Anaesthesia, 1984, Vol. 56, No. 6 617-626
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia

other

PHARMACOLOGY OF AN EMULSION FORMULATION OF ICI 35 868

J. B. GLEN and S. C. HUNTER

Medical Department, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire
Bioscience Department II, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire

Studies with an emulsion formulation of ICI 35 868 (2,6-diisopropylphenol) indicate that this new formulation has anaesthetic properties in rats and mice, and haemodynamic effects in the mini-pig which are similar to those of the previously available Cremophor formulation. Administration of the emulsion formulation to dogs produced no untoward effect, whereas the Cremophor formulation produced a marked increase in plasma histamine concentration. In the mini-pig, no adverse response was produced by the repeated administration of the emulsion formulation of ICI 35 868, whereas the Cremophor formulation produced anaphylactoid responses when a second injection was given 1 week after an uneventful first exposure to this formulation. Behavioural responses in the rat suggest that the emulsion formulation may produce less discomfort on i.v. injection


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