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British Journal of Anaesthesia, 1984, Vol. 56, No. 6 613-616
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia

other

INFUSION RATES FOR ANAESTHESIA WITH PROPOFOL

P. J. WRIGHT, R. S. J. CLARKE, J. W. DUNDEE, L. P. BRIGGS and A. A. GREENFIELD

Department of Anaesthetics, The Queen's University of Belfast Northern Ireland
Department of Clinical Anaesthetics, The Queen's University of Belfast Northern Ireland
Department of Medical Statistics, The Queen's University of Belfast Northern Ireland

The infusion rate of propofol which would produce anaesthesia, when combined with nitrous oxide in oxygen, was studied in 75 fit unpremedicated patients undergoing body surface operations. The infusion rates were based on multiples of the median dose required to produce anaesthesia by intermittent injection in an additional 20 patients. The scatter of doses showed a right skew, for both intermittent and continuous use. This was corrected by loge transformation and derived data presented graphically.

* Present address: Coombe Lying-in Hospital, Dublin


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