British Journal of Anaesthesia, 1984, Vol. 56, No. 6 599-605
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia
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USE OF ATRACURIUM IN CAESAREAN SECTION
Anaesthetics Uni, The London Hospital Medical College Whitechapel, London E1 IBB
Clinical Research Diviation, Wellcome Reseach Laboratories Beckenham, Kent BR3 3BS
Reprint srequests to R.H.
Correspondence to P. J. F
Following induction of anaesthesia with methohexitone, and tracheal intubation facilitated by suxamethonium, atracurium 0.3 mg kg1 was administered to 53 partients undergoing Caesarean section. surgical relaxation and cardiovascular blockade occured spontaneously in 45 patients and in the remaining eight patients, neostigmine and stropine produced rapid and effective antagonism. There was no evidence on recuraraization in any patient. In the neonates there were no adverse effects on Apgar scores or on the time to sustained respiration atributable to the use of atracurium. The drug concentration in the umbilical vein measured in 15 patients indicated that atracurium did not cross the placenta in amounts likely to be of clinical significance.