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British Journal of Anaesthesia, 1983, Vol. 55, No. 8 773-778
© 1983 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF MIDAZOLAM AND DIAZEPAM IN DOSES OF COMPARABLE POTENCY DURING GASTROSCOPY

J. G. WHITWAM, M.B., CH.B., PH.D., M.R.C.P., F.F.A.R.C.S, D. AL-KHUDHAIRI, M.B., CH.B., F.F.A.R.C.S.I*, and R. F. MCCLOY, M.B., B.S., B.SC., F.R.C.S

Department of Anaesthetics, Royal Postgraduate Medical School, Du Cane Road London
Department of Surgery, Royal Postgraduate Medical School, Du Cane Road London

Correspondence to J. G. W.

The water soluble bcnzodiazepine midazolam was compared with diazepam, in doses of 0.07 mg kg–1 and 0.l5 mg kg–1 respectively, administered i.v. to 100 patients undergoing gastroscopy. The degree of sedation, ease of endoscopy and recovery were comparable in the two groups. The effects of both drugs on arterial pressure were similar. Compared with diazepam, midazolam had a faster onset of effect, caused virtually no pain on injection, and provided a greater degree of amnesia.

*present address: Department of Anaesthetics, The Brompton Hospital, Fulham, London


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