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British Journal of Anaesthesia, 1983, Vol. 55, No. 8 735-741
© 1983 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PRETREATMENT WITH VECURONIUM AS A PROPHYLACTIC AGAINST POST-SUXAMETHONIUM MUSCLE PAIN

Comparison with other non-depolarizing neuromuscular blocking drugs

C. J. FERRES, M.B., B.CH., F.F.A.R.C.S.I., R. K. MIRAKHUR, M.D., PH.D., F.F.A.R.C.S., H. J. L. CRAIG, M.D., F.F.A.R.C.S., E. S. BROWNE, M.B.,B.S., F.F.A.R.C.S. and R. S. J. CLARKE, M.D., PH.D., F.F.A.R.C.S.

Department of Anaesthetics, The Queen's University of Belfast Belfast.
Royal Victoria Hospital Belfast 12

One hundred and ninety-eight patients undergoing minor surgery were assessed for evidence of post-suxamethonium muscle pain on the 1st and 2nd days following surgery. Patients were allocated to nine groups and were given one of four non-depolarizing neuromuscular blocking drugs (vecuronium, gallamine, tubocurarine or pancuronium) 1 or 2 min before the administration of suxamethonium. A control group received an inert medication. Forty-one per cent of patients receiving no pretreatment experienced muscle pain. This frequency was decreased to around 20% following pretreatment. In general, the frequency of pain was less in the groups receiving pretreatment at 1 min, but the difference was not significant. The groups receiving vecuronium before suxamethonium had the lowest overall frequency of pain over the 2 days (19%), although this was not significantly different from other pretreatments.


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