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British Journal of Anaesthesia, 1983, Vol. 55, No. 8 715-717
© 1983 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ASSESSMENT OF THE ALLERGENIC POTENTIAL OF ALTHESIN AND ITS CONSTITUENTS

P. TACHON, PHARM.D., J. DESCOTES, M.D. PHARM.D., A. LASCHI-LOQUERIE, PHARM.D., J. P. GUILLOT, PHARM.D. and J. C. EVREUX, M.D.

Institut Français de Toxicologie, Domaine des Oncins 69210 St Germain Sur L'Arbresle, France
Laborataire de Pharmacologie-Pharmacovigilance, Faculté de Médecine Alexis Carrel 69008 Lyon, France
Institut Pasteur de Lyon, Domaine de Poirier 69210 Lentilly, France

The pharmaceutical formulation of Althesin was shown to have a weak allergenic potential in the guineapig maximization test. Alphadolone and alphaxalone acetate were found to be devoid of such potential, while the status of Cremophor EL remained equivocal.


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