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British Journal of Anaesthesia, 1982, Vol. 54, No. 5 567-570
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECT OF NITROUS OXIDE ALONE OR ITS COMBINATION WITH FENTANYL ON SPINAL REFLEXES IN CATS

NAOSUKE SUGAI, M.D, PH.D, HIDETO MARUYAMA, M.D and KAZUHIRO GOTO

Department of Anesthesiology, University of Tokyo School of Medicine Hongo, Bunkyo-ku, Tokyo, Japan
Department of Rehabilitation, Teikyo University School of Medicine Itabashi-ku, Tokyo, Japan

The effects of nitrous oxide alone and combination of nitrous oxide and fentanyl on spinal reflexes were studied in cats with transected spinal cord at the thoracic level. Nitrous onde 33, 50 and 75% in oxygen depressed the amplitude of monosynaptic reflexes in a dose-dependent manner, but exerted little effect on polysynaptic reflexes. The addition of fentanyl 2.5 µg kg–1 during the administration of 75% nitrous oxide in oxygen depressed monosynaptic reflexes further. These results suggest that nitrous oxide or its combination with fentanyl has a depressant action on the transmission of monosynaptic reflexes in the spinal cord, but nitrous oxide might exert less effect on the spinal interneurones which mediate polysynaptic reflexes.


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