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British Journal of Anaesthesia, 1982, Vol. 54, No. 5 517-521
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF PHENTOLAMINE ON THE METABOLIC RESPONSE TO GYNAECOLOGICAL SURGERY

ELEANOR S. WALSH, B A, M B,B CH,B A O,D A,F F A R C S I, J. L. PATERSON, B SC, K. MASHITER, B SC, PH D* and G.M HALL, M B, B S, M I BIOL, PH D, F F.A R C S

*Medicine, Hammersmith Hospital, Royal Postgraduate Medical School Ducane Road, London W12 0HS
Departments of Anaesthetics and Royal Postgraduate Medical School Ducane Road, London W12 0HS

Correspondence to G.M.H.

The effect of the infusion of phentolamine 0.5 mg min–1 on the metabolic response to gynaecological surgery was investigated. In comparison with a control group of patients, phentolamine was associated with a significant increase in plasma insulin concentration after 30 and 60 min of surgery. The glycaemic response to surgery was decreased by {alpha}-adrenergic blockade, but this was only significant after 120 min of surgery. The hypotension produced by the administration of phentolamine was well tolerated.


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