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British Journal of Anaesthesia, 1982, Vol. 54, No. 5 513-516
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

BINDING OF TUBOCURARINE, FAZADINIUM, PANCURONIUM AND ORG NC 45 TO SERUM PROTEINS IN NORMAL MAN AND IN PATIENTS WITH CIRRHOSIS

PHILIPPE DUVALDESTIN, M.D and DANIÉLE HENZEL

Départment d'Anesthésie Hópital Bichat, 46, rue Henri-Huchard, 75018 Paris, France

The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocuranne, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal panents was 56% for tubocuranne, 51percnt; for fazadinium, 29% for pancuronium and 30percnt; for Org NC 45 In patients with cirrhosis, the protein binding of the four drugs was similar to that obtained in the normal patients.


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