British Journal of Anaesthesia, 1982, Vol. 54, No. 5 501-505
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia
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ANALGESIC RESPONSES TO I.V. LIGNOCAINE
Department of Anaesthesia, University of Massachusetts Medical Center Worcester, U.S A
The analgesic effect of i.v. lignocaine was evaluated in five patients with clinical neuralgic pain of varying aetiology. The response was compared with that on concurrently-induced ischaemic pain, initially of the same intensity Following a high dose infusion of 3 mg kg–1 (lignocaine concentrations greater than 3 µg ml–1 ) both pains were decreased, clinical pain to a significantly greater extent. Thereafter, at lower doses and blood concentrations, lignocaine was without effect on ischaemic pain, but almost totally suppressed the same patient's clinical pain. The results suggest a divergence in the specificity of the analgesic action of lignocaine I.V. according to the nature of the pain-inducing process. Disorders manifesting as deaffcrentation or central neuralgias appear to be affected favourably by lignocaine i.v., whereas pain of peripheral origin is unaffected by lignocaine, except at blood concentrations which approach toxic values.
*Present address for correspondence: Section of Anaesthetics, Department of Pharmacology and Clinical Pharmacology, University of Auckland School of Medicine, Auckland, New Zealand.
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