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British Journal of Anaesthesia, 1982, Vol. 54, No. 5 487-489
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

MATERNAL AND FETAL CONCENTRATION OF MORPHINE AFTER INTRATHECAL ADMINISTRATION DURING LABOUR

J. P BONNARDOT, C H.A R, M MAILLET, C H.A R, J.C. COLAU, F. MILLOT and P. DELIGNE

Departement d'Anesthesie Reanimation Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
Service de Gynecologie Obstetrique Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
Laboratoire de Biochimie Hopital Tenon 4 rue de la Chine, 75020 Paris, France

Twenty-five healthy women in labour received morphine 1-1 75 mg m normal saline intrathecally. The residual pain was evaluated on a scale from 0 to 5 at 10 mm (score 2.5) and at 25 mm (score 1.5). After delivery the maternal and fetal plasma morphine concentrations were measured by radioimmunoassay in 14 parturients Twenty-three women of 25 had vaginal deliveries, 20 of them without forceps The maternal and fetal plasma concentrations of morphine were 6 ng ml–1 or less. The intrathecal (but not extradural) administration of morphine is effective and could provide an interesting alternative for pain relief in labour.


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