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British Journal of Anaesthesia, 1982, Vol. 54, No. 11 1223-1230
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF INHALATION ANAESTHETIC AGENTS ON THE ELECTRICAL AND MECHANICAL ACTIVITY OF THE RAT DUODENUM

J. W. WRIGHT, T. E. J. HEALY, B SC., M.D, F F A.R.C.S, T. W. BALFOUR, M.B., CH.B., F R.C.S(ED) and J. D. HARDCASTLE, M.A, M CHIR., F R C S, M R C P

Department of Surgery, Floor E, University Hospital, Queens Medical Centre Nottingham
University Hospital of South Manchester Withington, Manchester M20 8LR

Sleep doses of halothane (4%), enflurane (2%) and diethyl ether (10%) were administered to fasting rats. Duodenal mechanical and electrical activities were recorded using miniature extraluminal strain gauges and silver/silver chloride bipolar electrodes. Halothane abolished, or significantly reduced, phase HI activity of the migrating myo-electnc complex whereas enflurane abolished phase II activity but failed to reduce phase HI. Ether was associated with periods of intense activity throughout anaesthesia and this activity persisted after recovery of consciousness. All anaesthetic agents caused a marked slowing of the basic electrical rhythm.


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