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British Journal of Anaesthesia, 1982, Vol. 54, No. 11 1197-1200
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF SODIUM NITROPRUSSIDE-INDUCED HYPOTENSION ON PULMONARY DEADSPACE

H. J. KHAMBATTA, M.D, J. G. STONE, M.D and R. S. MATTEO, M.D

Department of Anesthesiology, College of Physicians & Surgeons, Columbia University New York, N.Y. 10032 U.S.A.

Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio (VD/VT). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase VD/VT, and that vasodilataaon may bring about a relatively hypovolaemic state and be responsible for the increase in VD/VT observed by previous workers


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