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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1329-1335
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF A NEW ANALGESIC, MR 1268, ON CIRCULATORY AND RESPIRATORY INDICES IN VOLUNTEERS

I. O. SAMUEL, M.S., PH.D., R. S. J. CLARKE, M.D., PH.D., F.F.A.R.C.S., J. W. DUNDEE, M.D., PH.D., F.F.A.R.C.S., M.R.C.P. and J. J. WILSON, M.I.E.E.

Department of Anaesthetics, The Queen's University of Belfast Northern Ireland
Respiratory Intensive Care Unit, Royal Victoria Hospital Belfast

MR 1268, a benzmorphan derivative with marked morphine-like properties and weaker antagonist properties was administered to six healthy male volunteers who each received MR 1268 2.5,5,10 and 20 mg i.v. in random order. There were no significant changes in the cardiovascular indices measured. However, significant and dose-related decreases in expired minute volume were observed. With 20 mg, consistent increases in PaCO2 coincided With maximum decrease in ventilation, indicating some degree of alveolar hypoventilation. Drowsiness was dose-related but of short duration and only significant with 20 mg. Pupillary size and reaction remained unaffected.


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