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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1315-1320
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF ATROPINE AND GLYCOPYRROLATE IN A MIXTURE WITH PYRIDOSTIGMINE FOR THE ANTAGONISM OF NEUROMUSCULAR BLOCK

R. K. MIRAKHUR, M.D. PH.D. F.F.A.R.C.S.*, L. P. BRIGGS, M.B., F.F.A.R.C.S., R. S. J. CLARKE, M.D. PH.D., F.F.A.R.C.S., J. W. DUNDEE, M.D., PH.D., F.F.A.R.C.S. and H. M. L. JOHNSTON, M.B., F.F.A.R.C.S.*

Department of Anaesthetics, Queen s University Belfast
*Present address: Department of Anaesthesia, Royal Victoria Hospital Belfast BT126BA

Neuromuscular block was antagonized using pyridostigmine 250 µg kg–1 in two groups of 50 patients; one group received atropine 20µg kg–1 and the other glycopyrrolate 10 µg kg–1 with the anticholinesterase drug. Atropine was associated with a greater initial tachycardia than was glycopyrroUte. The subsequent bradycardia was also greater in this group, although the decreases in heart rate were smaller than those generally observed following mixtures of atropine and neostigmine. Arrhythmias were transient and required no treatment in either group. Better control of secretions was achieved with glycopyrrolate.


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