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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1291-1302
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ALFENTANIL-OXYGEN ANAESTHESIA FOR CORONARY ARTERY SURGERY

S. DE LANGE, M.B.B.S., F.F.A.R.C.S., T. H. STANLEY, M.D.* and M. J. BOSCOE, M.B.B.S., F.F.A.R.C.S.

Department of Cardiothoracic Anaesthesiology, University of Leiden Hospital Leiden, The Netherlands

*Correspondence to T.H.S., Department of Anaesthesiology, University of Utah College of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, U.S.A.

The anaesthetic properties of alfentanil were evaluated in 15 patients undergoing coronary artery bypass grafting operations. Alfentanil was infused at a rate of 3.0 mg min–1 until the patients (breathing pure oxygen) became unconscious. Additional alfentanil 2.5–5.0 mg i.v. was given if systolic arterial pressure increased by 15% or more from control values. Alfentanil produced unconsciousness in 75±18s, but muscle rigidity occurred in 27% of patients. Cardiovascular dynamics were minimally altered during the induction of anaesthesia and throughout most of the operation, although 60% of patients became hypertensive during stemotomy and 73% during sternal spread. Recovery from anaesthesia was rapid with patients regaining consciousness after 1.4±0.6 h and fulfilling our criteria for extubation of the trachea 4.1±1.2 h after operation. No patient was aware of laryngoscopy, endotracheal intubation or any aspect of the operation.


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