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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1281-1284
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PLASMA PROTEIN CONCENTRATION AND RECOVERY FROM ANAESTHESIA IN MAN

G. TORRI, M.D., PH.D., L. STELLA, M.D., G. PRADELLA, M.D., E. MAESTRONE, M.D. and C. MARTANI, M.D.

Universitá di Milano Settore Didattico Ospedale S. Raffaele, via Olgettina 60, 20090-Milano, Italy
Servizio di Anestesia e Rianimazione, Ospedale Civile, Sondrio, Italy

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The effect of the concentration of plasma protein on the recovery from anaesthesia induced by equipotent doses (UD95) of thiopentone and Althesin was studied in 48 patients. The recovery time (RT) was plotted against the concentrations of total plasma proteins (TPP) and albumin (Al). A small decrease in TPP concentration from normal range affected the recovery time minimally; a small decrease in TPP concentration from a low basal value markedly increased the recovery rime with both agents. A large decrease in TPP concentration increased the recovery time from thiopentone and Althesin markedly.


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