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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1273-1276
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

GLYCOPYRROLATE IN CHILDREN

P. WARRAN, M.B., CH.B., F.F.A.R.C.S., P. RADFORD, M.B., B.S., F.F.A.R.C.S. and M.B., B.S., F.F.A.R.C.S. MANFORD

Department of Anaesthetics, Queen Mary's Hospital for Children Carshalton, Surrey SM5 4NR

Correspondence to P. R.

The effects of glycopyrrolate 10µg kg–1 i.v.given at induction of anaesthesia were compared with those of atropine 20µg kg–1 i.v. given at induction and oral atropinc 30µg kg–1 given 90 min before operation. Antisialagogue effect, changes in axillary temperature, heart rate, frequency of cardiac arrhythmia and postoperative restlessness were determined. Patients who had received oral atropine had more pharyngeal secretions, a lower heart rate and a greater frequency of cardiac arrhythmia than when either atropine or glycopyrrolate was given i.v. Secretions were significantly less during operation when i.v. glycopyrrolate was used.


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