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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1259-1264
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CONTROLLED-RELEASE MORPHINE TABLETS

A double-blind trial in dental surgery patients

G. W. HANKS, M.B., B.S., M.R.C.P.(U.K.), N. M. ROSE, M.A., B.M., B.CH., F.F.A.R.C.S.*, G. W. AHERNE, B.SC., PH.D., E. M. PIALL, B.SC., S. FAIRFIELD, B.A., S.R.N. and T. TRUEMAN, S.R.N.

Sir Michael Sobell House, Churchill Hospital Headington, Oxford OX3 7LJ
Nuffield Department of Anaesthetics, The Radcliffe Infirmary Oxford OX2 6HE
Department of Clinical Biochemistry, University of Surrey Guildford GU2 5XH
*Present address: Worcester Royal Infirmary Castle Street, Worcester

We report a randomized double-blind comparison of controlled-release morphine tablets (MST-1; 2 x 10 mg) and oral morphine sulphate in solution (20 mg) in 28 patients (20 females) who had undergone removal of impacted lower third molars or a dental clearance under general anaesthetic. The response in both groups was very poor: eight of 15 patients in MST-1 group and six of 13 patients in the standard group required "rescue" analgesics and were withdrawn from the study within the first 2h. No threshold plasma concentration of morphine corresponding to a particular analgesic effect was apparent. MST-1 produced significantly greater plasma concentrations at 8h compared with the standard preparation. Controlled-release morphine, or any oral formulation of morphine, may not be suitable for the treatment of acute pain after operation.


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