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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1247-1257
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

A METHOD FOR ACHIEVING RAPIDLY STEADY-STATE BLOOD CONCENTRATIONS OF I.V. DRUGS*

J. R. A. RIGG, M.B., B.S., F.F.A.R.A.C.S.{dagger} and T. Y. WONG, M.SC.

Department of Anaesthesia, McMaster University 1200 Main Street West, Hamilton, Ontario, Canada

{dagger}Present address for correspondence: Centre for Advanced Studies, Division of Health Sciences, Western Australian Institute of Technology, Hayman Road, South Bentley, Western Australia, 6102

The theoretical basis of a pharmacokinetic method to obtain rapidly and maintain a steady plasma concentration of an i.v. drug is described. Computer simulations of morphine disposition in man, using pharmacokinetic constants obtained from the literature, are provided as examples of steady-state dose regimens. The usefulness and potential limitations of the method are discussed.

*Presented in part at the 1978 meeting of the Canadian Anaesthetists' Society; the V European Congress of Anesthesiology, Paris 1978, and the 1979 meetings of the American Society for Clinical Pharmacology and Therapeutics, Kansas City, and the Australian Society of Anaesthetists, Adelaide, Australia.


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