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British Journal of Anaesthesia, 1981, Vol. 53, No. 1 59-64
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

WY 16225 (DEZOCINE), A NEW SYNTHETIC OPIATE AGONIST-ANTAGONIST AND POTENT ANALGESIC: COMPARISON WITH MORPHINE FOR RELIEF OF PAIN AFTER LOWER ABDOMINAL SURGERY

J. W. DOWNING, M.B., B.CH.(RAND), F.F.A.(S.A.), F.F.A.R.C.S.(ENG), J. G. BROCK-UTNE, M.A., M.B., B.CH., F.F.A.(S.A.), CAND. MED.(BERGEN), A. BARCLAY, M.B., B.S., D.A., F.F.A.(S.A.) and I. L. SCHWEGMANN, S.R.N.

Department of Anaesthetics P.O. Box 17039, Congella, 4013, Durban, South Africa

Dezocine (Wy 16225), a new analgesic was compared randomly and double-blind with morphine 10 mg in 160 female patients complaining of moderate (group I) or severe (group II) pain after elective lower abdominal surgery; both drugs were given i.m. In group I, pain relief with dezocine 10 and 15 mg was significantly greater than dezocine 5 mg; dezocine 10 mg appeared equipotent with morphine 10 mg. Similar, but statistically insignificant differences were observed in group II. Patient sedation was minimal and untoward side-effects infrequent with all doses of the trial drugs.


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