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British Journal of Anaesthesia, 1981, Vol. 53, No. 1 55-58
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ADVERSE RESPONSES TO I.V. ANAESTHETICS

D. BEAMISH, F.F.A.R.C.S. and D. T. BROWN, F.F.A.R.C.S.

Department of Anaesthetics, Royal Infirmary Edinburgh EH3 9YW

The adverse reactions to i.v. anaesthetics which occurred during a 3-yr period in one hospital were investigated. Sixteen reactions were reported; 13 of these occurred in a total of 7906 administrations of Althesin, two in 45 546 administrations of thiopentone and one in 630 administrations of methohexitone. The pathological process was identified in 10 patients. Most reactions were caused by activation of the alternate pathway for complement conversion.


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