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British Journal of Anaesthesia, 1981, Vol. 53, No. 1 5-10
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

ANAESTHETIC REQUIREMENT IN MICE SELECTIVELY BRED FOR DIFFERENCES IN ETHANOL SENSITIVITY

D. D. KOBLIN, PH.D. and J. E. DEADY, M.S.

Department of Anesthesia (HSE 1386), University of California San Francisco, California 94143, U.S.A.

Anaesthetic requirements for nitrous oxide, enflurane and isoflurane were determined in mice selectively bred for their susceptibility ("long-sleep" mice) or resistance ("short-sleep" mice) to alcohol. Nitrous oxide and enflurane requirements, measured by the rolling-response test, were 34 and 20% greater, respectively, in short-sleep mice than in long-sleep mice. Although isoflurane requirement was 39% greater when measured by the tail-clamp test, it was not significantly different when measured by the rolling-response test. The greater anaesthetic requirement for short-sleep mice was not associated with a different synaptic membrane phospholipid, fatty acid or cholesterol composition.


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