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British Journal of Anaesthesia, 1981, Vol. 53, No. 1 27-30
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS AND ANALGESIC EFFECT OF KETAMINE IN MAN

J. A. CLEMENTS, PH.D. and W. S. NIMMO, M.R.C.P., F.F.A.R.C.S.

Department of Pharmacy, Heriot Watt University Edinburgh
University Department of Anaesthesia, Western Infirmary Glasgow G11 6NT.

The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 µg kg–1 and 250 µg kg–1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml–1. Ketamine was distributed rapidly (T1/2z=17 min). The elimination half-life was 186 min.


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