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British Journal of Anaesthesia, 1981, Vol. 53, No. 1 19-26
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

INTERACTIONS OF ADRENERGIC BETA-RECEPTOR BLOCKADE (OXPRENOLOL) AND Pco2 IN THE ANAESTHETIZED DOG: INFLUENCE OF INTRINSIC BETA-SYMPATHOMIMETIC ACTIVITY

P. FOËX, M.A., D.PHIL., D.M.(GENEVA) and W. A. RYDER

Nuffield Department of Anaesthetics, The Radcliffe Infirmary Oxford OX2 6HE

Effects of change in Paco2 on systemic and coronary haemodynamics and on coronary sinus blood-gases have been studied in 10 open-chested dogs in which the lungs were ventilated with 0.8% halothane in oxygen, before and after administration of oxprenolol 0.3 mg kg–1 i.v. The hyperdynamic response of the circulation to hypercapnia was only marginally reduced after oxprenolol (cardiac output increased by 10% as opposed to 16% before oxprenolol). Before and after oxprenolol, hypocapnia caused large reductions of coronary blood flow (–24% and –20% respectively), while hypercapnia caused large increases of coronary blood flow (+59% and +34% respectively). Oxprenolol does not appear to modify significantly the circulatory response to arterial carbon dioxide tension.


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