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British Journal of Anaesthesia, 1980, Vol. 52, No. suppl_1 49S-52S
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

First Clinical Experiences with ORG NC 45

J. F. Crul, M.D., PH.D., F.FA.R.C.S. and L. D. J. Booij, M.D.

Department of Anesthesiology, University Hospital Geert Groote Plein Zuid 12, Nijmegen, The Netherlands

The new short-acting steroid muscle relaxant Org NC 45 was tested clinically in 18 patients and compared with a similar application of pancuronium bromide in 22 patients. Onset, duration and slope of recovery were significantly shorter for Org NC 45. No cumulative effects were noticed over several consecutive doses of Org NC 45. No tachycardia or arterial pressure changes were noticed with doses of Org NC 45 up to 130 µg kg–1 which was three times the 95% blocking dose.


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