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British Journal of Anaesthesia, 1980, Vol. 52, No. suppl_1 43S-47S
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Use of the Human "Isolated Arm" Preparation to Indicate Qualitative Aspects of a New Neuromuscular Blocking Agent, ORG NC 45

A. Bencini, M.D., F.F.A.R.C.S., S. Agoston, M.D., P.H.D. and J. Ket

Research Group of the Institutes of Anaesthesiology and Clinical Pharmacology, State University of Groningen Oostersingel 59, Groningen, The Netherlands

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In the human isolated arm preparation Org NC 45 had a significantly faster rate of recovery and a shorter duration of action (end of injection to 90% recovery of control twitch height) than pancuronium. The isolated arm preparation is suitable for the qualitative comparison of the neuromuscular blocking activities of new and established drugs.


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