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British Journal of Anaesthesia, 1980, Vol. 52, No. suppl_1 37S-41S
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Pharmacokinetics and Pharmacodynamics of ORG NC 45 in Man

F. Van Der Veen and A. Bencini, M.D.

Scientific Development Group, Organon International B.V. Oss, The Netherlands
Department of Anaesthesia. University of Groningen Groningen, The Netherlands

Correspondence to F. van der Veen

A combined pharmacokinetic-pharmacodynamic study of Org NC45 was performed in six patients undergoing elective oro-facial surgery. The pharmacokinetics could be described using a two-compartment open model with a distribution half-life of approximately 4 min and an elimination half-life of approximately 31 min. The pharmacokinetic parameters confirm earlier clinical findings that Org NC 45 has a more rapid onset and a shorter duration of action than pancuronium, and a faster recovery rate. When comparing the pharmacokinetic and pharmacodynamic parameters the biophase could be distinguished from both the central and the peripheral compartments. The mean steady-state plasma concentration producing a 50% block of the twitch response was 0.137 µg ml–1 (range 0.118—0.176 µg ml–1).


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