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British Journal of Anaesthesia, 1980, Vol. 52, No. suppl_1 33S-36S
© 1980 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

Preliminary Review of the Interactions of ORG NC 45 with Anaesthetics and Antibiotics in Animals

N. Krieg, M.D., J. M. J. Rutten, M.D., J. F. Crul, M.D., PH.D. and L. H. D. J. Booij, M.D.

Department of Anaesthesiology, Catholic University, St Ratiboud Hospital Geert Groote Plein Zuid 12, Nijmegen, The Netherlands

Reprint requests to N. K.

In vitro (rat hemidiaphragm) and in vivo (rat and cat ubialis anterior muscle preparation) studies of the interactions between Org NC 45 and some i.v. anaesthetics and antibiotics were carried out. With the exception of ketamine 1 mg kg-1none of the drugs tested in vivo significantly changed the time course of an Org NC 45 bolus injection. All of the drugs caused an enhancement of the neuromuscular block using infusions in vivo and also in the in vitro preparations. Org NC 45 seems to be potentiated in a manner similar to pancuronium.


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